Research Interests

St. George's, University of London
www.sgul.ac.uk/research-profiles-a-z/marios-papadopoulos

Our aim is to improve outcome after human spinal cord injury by developing novel surgical and intensive care techniques.
http://www.wingsforlife.com/en/latest/under-pressure-1448/ 
https://player.vimeo.com/video/196608157

Selected publications
  1. Gallagher MJ, Hogg FRA, Zoumprouli A, Papadopoulos MC, Saadoun S (2018). Spinal Cord Blood Flow in Patients with Acute Spinal Cord Injuries. J Neurotrauma. [Epub]
  2. Hogg FRA, Gallagher MJ, Chen S, Zoumprouli A, Papadopoulos MC, Saadoun S (2018). Predictors of Intraspinal Pressure and Optimal Cord Perfusion Pressure After Traumatic Spinal Cord Injury. Neurocrit Care.  [Epub]
  3. Gallagher MJ, Zoumprouli A, Phang I, Schwab JM, Kopp MA, Liebscher T, Papadopoulos MC, Saadoun S (2018). Markedly Deranged Injury Site Metabolism and Impaired Functional Recovery in Acute Spinal Cord Injury Patients With Fever. Crit Care Med 46:1150-1157.
  4. Chen S, Gallagher MJ, Hogg F, Papadopoulos MC, Saadoun S. Visibility Graph Analysis of Intraspinal Pressure Signal Predicts Functional Outcome in Spinal Cord Injured Patients. J Neurotrauma 35:2947-2956.
  5. Chen S, Smielewski P, Czosnyka M, Papadopoulos MC, Saadoun S (2017). Continuous Monitoring and Visualization of Optimum Spinal Cord Perfusion Pressure in Patients with Acute Cord Injury. J Neurotrauma 34:2941-2949.
  6. Saadoun S, Chen S, Papadopoulos MC (2017). Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury. J Neurol Neurosurg Psychiatry 88:452-453.
  7. Saadoun S, Papadopoulos MC (2016). Spinal cord injury: is monitoring from the injury site the future? Crit Care 2016;20(1):308.
  8. Phang I., Zoumprouli A, Papadopoulos MC, Saadoun S (2016). Microdialysis to optimize cord perfusion and drug delivery in spinal cord injury. Ann Neurol 80:522-31.
  9. Phang I., Zoumprouli A, Saadoun S, Papadopoulos MC (2016). Safety profile and probe placement accuracy of intraspinal pressure monitoring for traumatic spinal cord injury. J Neurosurg Spine 25:398-405.
  10. Phang I, Werndle MC, Saadoun S, Varsos GV, Czosnyka M, Zoumprouli A, Papadopoulos MC (2015). Expansion duroplasty reduces intraspinal pressure and increases spinal cord perfusion pressure after traumatic spinal cord injury. J Neurotrauma 32;865-74.
  11. Verkman AS, Anderson MO, Papadopoulos MC (2014). Aquaporins, important but elusive drug targets. Nature Rev Drug Discov 13:259-77.
  12. Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos G, Czosnyka Z, Smielewski P, Jamous A, Bell BA, Zoumprouli A, Papadopoulos MC (2014). Monitoring of spinal cord perfusion pressure in acute spinal cord injury. Crit Care Med 42:646-55.
  13. Papadopoulos MC, Bennett JL, Verkman AS (2014). Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nature Rev Neurol 10:493-506.
  14. Saadoun S, Waters P, Leite MI, Bennett JL, Vincent A, Papadopoulos MC (2013). Neuromyelitis optica IgG causes placental inflammation and fetal death. J Immunol 191:2999-3005.
  15. Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC (2012). Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol 71:323-33.
  16. Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica (2012). Ann Neurol 71:314-22.
  17. Papadopoulos MC, Verkman AS (2012). Aquaporin 4 and neuromyelitis optica. Lancet Neurol 11:535-44.
  18. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC (2010). Intra-cerebral injection of NMO-IgG and human complement produces neuromyelitis optica lesions in mice. Brain 133:349-61. 
  19. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC (2008). Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain 131:1087-98.
  20. Tait MJ, Saadoun S, Bell BA, Papadopoulos MC (2008). Water movements in the brain: role of aquaporins. Trends Neurosci 31:37-43.
  21. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS (2005). Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci 118:5691-8.
  22. Papadopoulos MC, Verkman AS (2005). Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem 280:13906-12.
  23. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005). Targeted aquaporin-1 gene disruption impairs angiogenesis and cell migration. Nature 434:786-92.
  24. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS (2004). In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci 24:8049-56.
  25. Papadopoulos MC, Manley GT, Krishna S, Verkman AS (2004). Aquaporin 4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB Journal 18:1291-3.
  26. Saadoun S, Papadopoulos MC, Davies DC, Krishna S, Bell BA (2002). Oedematous human brain tumours have increased aquaporin-4 expression. J Neurol Neurosurg Psych 72:262-5.

Complete publication list 

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=papadopoulos+mc

Bibliometrics

Google Scholar: https://scholar.google.co.uk/citations?user=eJ13XCEAAAAJ&hl=en

Funding

Wings for Life: http://www.wingsforlife.com/en/
Neurosciences Research Foundation:  http://www.neurosciencesresearchfoundation.org.uk